Semaglutide Plus Trevogrumab Combo Superior Fat Loss with Reduced Muscle Wasting

by sharpshadowon 6/4/2025, 8:22 PMwith 2 comments

by floxyon 6/4/2025, 8:35 PM

Is there a way to quantify the "expected" muscle loss associated with extreme weight loss? I mean, for people who go from 400 lbs to 150 lbs, prior to the weight loss, they were essentially doing a 250 pound squat ever time they'd get up and out of a chair. I assume most people don't start taking up weight lifting, so then they'd lose a lot of muscle mass they are no longer are using.

by toomuchtodoon 6/5/2025, 1:07 AM

The triplet therapy arm combining semaglutide, trevogrumab, and garetosmab is very compelling, but they’re going to have to get the treatment-emergent adverse events worked out.